| 7th Aug 09 | 7:00 PM | AC Ajaccio vs Guingamp | L2 | 0 - 1 |
| 14th Aug 09 | 7:00 PM | Guingamp vs Angers SCO | L2 | 0 - 0 |
| 20th Aug 09 | 5:45 PM | Guingamp vs Hamburg SV | Europa League | 1 - 5 |
| 23rd Aug 09 | 6:00 PM | Guingamp vs Vannes OC | L2 | 4 - 1 |
| 27th Aug 09 | 7:00 PM | Hamburg SV vs Guingamp | Europa League | 3 - 1 |
| 30th Aug 09 | 7:00 PM | Tours FC vs Guingamp | L2 | 2 - 0 |
| 4th Sep 09 | 7:00 PM | FC Istres vs Guingamp | L2 | 0 - 0 |
| 11th Sep 09 | 7:30 PM | Guingamp vs SM Caen | L2 | 0 - 0 |
| 18th Sep 09 | 7:30 PM | Stade Brestois vs Guingamp | L2 | 2 - 0 |
| 25th Sep 09 | 7:00 PM | Guingamp vs SC Bastia | L2 | 1 - 1 |
| 2nd Oct 09 | 7:00 PM | Nimes Olympique vs Guingamp | L2 | 2 - 0 |
| 16th Oct 09 | 7:00 PM | Guingamp vs Dijon FCO | L2 | 1 - 1 |
| 23rd Oct 09 | 7:00 PM | FC Metz vs Guingamp | L2 | 2 - 0 |
| 26th Oct 09 | 7:45 PM | Guingamp vs Harve AC | L2 | 1 - 2 |
| 30th Oct 09 | 7:00 PM | Stade Lavallois vs Guingamp | L2 | 3 - 0 |
| 9th Nov 09 | 7:45 PM | FC Nantes vs Guingamp | L2 | 0 - 2 |
| 27th Nov 09 | 7:00 PM | Guingamp vs AC Arles-Avignon | L2 | 4 - 1 |
| 1st Dec 09 | 7:00 PM | LB Chateauroux vs Guingamp | L2 | 0 - 1 |
| 4th Dec 09 | 7:00 PM | Guingamp vs CS Sedan | L2 | 2 - 2 |
| 18th Dec 09 | 7:30 PM | RC Strasbourg vs Guingamp | L2 | 2 - 1 |
| 22nd Dec 09 | 7:00 PM | Guingamp vs Clermont Foot | L2 | 1 - 1 |
| 10th Jan 10 | 1:30 PM | Bonchamp Les Laval vs Guingamp | CDF | 0 - 2 |
| 13th Jan 10 | 4:00 PM | Guingamp vs Paris Saint-Germain | CDL | 1 - 0 |
| 16th Jan 10 | 4:00 PM | Angers SCO vs Guingamp | L2 | 1 - 0 |
| 19th Jan 10 | 7:00 PM | Guingamp vs FC Istres | L2 | 0 - 0 |
| 24th Jan 10 | 1:30 PM | Mulhouse vs Guingamp | CDF | 0 - 1 |
| 27th Jan 10 | 5:45 PM | Guingamp vs Toulouse FC | CDL | 0 - 1 |
| 30th Jan 10 | 7:00 PM | Vannes OC vs Guingamp | L2 | 2 - 2 |
| 5th Feb 10 | 7:00 PM | Guingamp vs Tours FC | L2 | 2 - 2 |
| 9th Feb 10 | 5:15 PM | U.S. Boulogne vs Guingamp | L2 | - |
| 12th Feb 10 | 7:00 PM | SM Caen vs Guingamp | L2 | - |
| 21st Feb 10 | 2:00 PM | Guingamp vs Stade Brestois | L2 | - |
| 26th Feb 10 | 7:00 PM | SC Bastia vs Guingamp | L2 | - |
| 5th Mar 10 | 7:00 PM | Guingamp vs Nimes Olympique | L2 | - |
| 12th Mar 10 | 7:00 PM | Dijon FCO vs Guingamp | L2 | - |
| 19th Mar 10 | 7:00 PM | Guingamp vs FC Metz | L2 | - |
| 26th Mar 10 | 7:00 PM | Harve AC vs Guingamp | L2 | - |
| 2nd Apr 10 | 7:00 PM | Guingamp vs Stade Lavallois | L2 | - |
| 9th Apr 10 | 7:00 PM | Guingamp vs FC Nantes | L2 | - |
| 16th Apr 10 | 7:00 PM | AC Arles-Avignon vs Guingamp | L2 | - |
| 23rd Apr 10 | 7:00 PM | Guingamp vs LB Chateauroux | L2 | - |
| 30th Apr 10 | 7:00 PM | CS Sedan vs Guingamp | L2 | - |
| 4th May 10 | 7:00 PM | Guingamp vs RC Strasbourg | L2 | - |
| 7th May 10 | 7:00 PM | Clermont Foot vs Guingamp | L2 | - |
| 14th May 10 | 7:00 PM | Guingamp vs AC Ajaccio | L2 | - |
